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ea0090ep26 | Adrenal and Cardiovascular Endocrinology | ECE2023

Optimal application of captopril challenge test in the diagnosis of primary aldosteronism

Chen Wenzhan , Chen Nan , Yu Shuang , Zeng Rui , Chen Li , Xu Changliu , Li Yanbing , Xiao Haipeng , Cao Xiaopei

Objective: To evaluate the optimal parameters and the cut-off points of captopril challenge test (CCT) in the diagnosis of primary aldosteronism (PA) using chemiluminescence immunoassays (CLIA).Methods: Patients with clinically suspected PA who admitted to our hospital between July 2021 and December 2021 were recruited. Both supine and upright aldosterone to renin ratio (ARR) were calculated in all the participants and 21 healthy volunteers. CCT was perf...

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ea0035p736 | Nuclear receptors and signal transduction | ECE2014

Formation of progesterone receptor-NF-κB complex is required for progesterone-induced NF-κB nuclear translocation and binding onto the p53 promoter

Hsu Sung-Po , Yang Ho-Ching , Kuo Chun-Ting , Wen Heng-Ching , Chen Li-Ching , Huo Yen-Nien , Lee Wen-Sen

We previously showed that progesterone (P4) regulates p53 expression and cell cycle progress in human umbilical venous endothelial cells (HUVEC) through progesterone receptor (PR) activation of extra-nuclear signaling pathways. Here, we showed that P4 activated the PR and hence increased the formation of progesterone receptor A-(PR-A)-NF-κB complex in both the cytosol and the nucleus. Chromatin immunoprecipitation demonstrated an interaction between PR and the NF-κB ...

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Endocrine Abstracts

Optimal application of captopril challenge test in the diagnosis of primary aldosteronism

Formation of progesterone receptor-NF-κB complex is required for progesterone-induced NF-κB nuclear translocation and binding onto the p53 promoter

BiosciAbstracts